Our laboratory investigates how chromatin regulation and nuclear condensates control gene expression and cell fate, and how their dysregulation drives cancer. We employ multidisciplinary approaches to uncover these mechanisms and translate our discoveries into therapeutic strategies. The Wan Lab is affiliated with the Department of Cancer Biology, Abramson Family Cancer Research Institute, Penn Epigenetics Institute, and Institute for Regenerative Medicine at the Perelman School of Medicine, University of Pennsylvania.

Latest News

August 2026: Our spotlight titled ‘A New Phase in KRAS Signaling’ is now online! Check here to learn more

June 2026: Our study revealing how RNA reinforces condensate nucleation to amplify oncogenic transcription is now published in Molecular Cell! Check here to learn more

June 2026: Krista successfully defended her thesis, becoming the first Ph.D. student to graduate from the Wan Lab! Congratulations, Dr. Budinich!

In the Media

Interested in joining?

We are constantly looking for talented and passionate researchers (postdocs, graduate students, undergraduate and research technicians) to join our growing team! Please see Open Positions and contact Dr. Wan if interested.